Modulation of hemi/cellulase gene transcription for improved feed independent production of cellulolytic enzymes by Trichoderma reesei

01.10.2009 - 31.12.2018
Assigned research project
The cellulolytic enzyme dosage required for efficient cellulose hydrolysis during the cellulose-to-ethanol (¿Cellulosic Ethanol¿). process is very high and the cost of enzymes is a significant factor in overall biorefinery operating costs. Thus, the development of cost-effective cellulase enzymes is critical to the success of a commercial ethanol process. One of the approaches for reducing enzyme production cost is the use of alternative low cost carbon sources (e.g. lignocellulose hydrolysates comprising glucose, xylose and arabinose). Currently, one of the major technological approaches requires addition of costly cellulase-inducing carbohydrates into Trichoderma fermentation media. Further cost reduction could be realized if production of high-quality cellulases can be achieved in the absence of cellulase inducers and during fermentation on low cost carbon sources (e.g. lignocellulose hydrolysates). The project focuses on genetic engineering of Trichoderm. reesei to achieve these goals.

People

Project leader

Sub project leader

Project personnel

Institute

Contract/collaboration

  • Iogen Corp

Research focus

  • Efficient Utilisation of Material Resources: 50%
  • Sustainable Production and Technologies: 50%

Keywords

GermanEnglish
TrichodermaTrichoderma
Hemi/Cellulasenhemi/cellulases
Genregulationgene regulation
Lignocelluloselignocellulose
Bio-Ethanolbio-ethanol

External partner

  • ENVIRO OEG Environmental Research Group

Publications