The aim is, to carry out reaction cascades under solvent-free conditions, without isolation and purification of intermediate products. In the first step of a sequence, the reagents are added to a milling vessel and the reaction is typically carried out in a ball mill. After the first transformation, the milling vessel is opened, and the additional reagents for the next step are added. Ideally, multi-step syntheses can be carried out without isolation and purification of any intermediate and only the final product is isolated.
