Forschungsschwerpunkte sind Theorie und Anwendungen der Modellierung und Simulation von dynamischer und komplexer Systeme, insbesondere: vergleichende Modellierung und Simulation; Kopplung und Vergleich mathematischer Modellansätze; Entwicklung neuer Modellierungsmethoden; Implementierung, Parametrisierungs -, Kalibrierungs - und Validierungskonzepte sowie Domänen - und Anwendungsintegration von Simulationsmodellen, wie Gesundheitssystemforschung und modellbasierte HTA (health technology assessment).

Senior Scientist TU WIen, Direktor DEXHELPP (Decision Support for Health Policy and Planning) ehem. COMET Projekt, CSO TU Spin OFF dwh GmbH, Gründer "die Drahtwarenhandlung" Wissenschaftsfilm & Datenjournalismus

ISPOR (International Society For Pharmacoeconomics and Outcomes Research), Founding President ISPOR Austrian Chapter, Member of the ISPOR Modeling Review Group, SMDM (Society for Medical Decision Making) Member, EUROSIM (Federation of European Simulation Societies), Secretary and Chair of Technical Committee “Data Driven System Simulation”, ASIM (Arbeitsgemeinschaft Simulation - Simulation Society of German Speaking Countries), Board Member, Vice Spokesperson “Methods in Modelling and Simulation“ & “Environmental and Geo Sciences, Medicine and Biology”

Main research interests are theory and applications of modelling & simulation of dynamic and complex systems, especially: comparative modelling & simulation; coupling and comparison of mathematical model approaches; implementation, parametrization, calibration and validation concepts and domain and application integration of simulation models and Health Outcome Research. Niki Popper is chairman of the COMET Initiative DEXHELPP (Decision Support for Health Policy and Planning)

Director DEXHELPP (Decision Support for Health Policy and Planning) ehem. COMET Projekt, CSO TU Spin OFF dwh GmbH, Founder "die Drahtwarenhandlung" Science Productions & Data Journalism.

ISPOR (International Society For Pharmacoeconomics and Outcomes Research), Founding President ISPOR Austrian Chapter, Member of the ISPOR Modeling Review Group, SMDM (Society for Medical Decision Making) Member, EUROSIM (Federation of European Simulation Societies), Secretary and Chair of Technical Committee “Data Driven System Simulation”, ASIM (Arbeitsgemeinschaft Simulation - Simulation Society of German Speaking Countries), Board Member, Vice Spokesperson “Methods in Modelling and Simulation“ & “Environmental and Geo Sciences, Medicine and Biology”