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Nuclear traffic and cellulase production in Trichoderma
01.04.2011 - 30.11.2014
Forschungsförderungsprojekt
Trichoderma reesei (teleomorph Hypocrea jecorina) is the main industrial source of cellulases and hemicellulases used for the hydrolysis of biomass to simple sugars, which can then be converted to biofuels, such as ethanol, and other chemicals. The strains in use today have been obtained by classical mutagenesis. In order to learn how cellulase production was improved by these techniques, we previously used Illumina next generation sequencing technologies to identify mutations in the genomes of two hyperproducing mutants (NG14, and its direct improved descendant, RUT C30). Thereby, we detected several mutated genes that were mainly in nuclear transport, thus making nuclear traffic a potential pacemaker in cellulase production. In this project, we plan a systematic study on the importins and exportins responsible for nuclear traffic of the main cellulase regulator XYR1, and propose a strategy aimed at testing which of these components is actually rate limiting to cellulase gene expression.
Personen
Projektleiter_in
Peter Christian Kubicek
(E166)
Projektmitarbeiter_innen
Lea Atanasova
(E166)
Sara Ghassemi
(E166)
Sabine Gruber
(E166)
Silvia Herold
(E166)
Institut
E166 - Institute of Chemical, Environmental and Bioscience Engineering
Grant funds
FWF - Österr. Wissenschaftsfonds (National)
Austrian Science Fund (FWF)
Forschungsschwerpunkte
Beyond TUW-research focus: 100%
Schlagwörter
Deutsch
Englisch
Trichoderma
Trichoderma
Kerntransport
nuclear transport
Cellulase
cellulase
Biotreibstoffe
Biofuels
Gentechnik
gene technology
Publikationen
Publikationsliste