Aging of the skin is the most visible and obvious manifestation of organismal aging and serves as a predictor of life expectancy and health even to the layperson. It is however also the human desire for long‐lasting beauty that further raises broad interest in the topic as a field of basic and applied research. Modern urban lifestyle involves exposure to pollution combined with recreational outdoor exposure to sun, and both are major external promotors of skin aging. Moreover, the accumulation of senescent cells in the aging tissue is a major cause for visible signs of skin aging, while pollution and sunlight further promote cellular senescence. The skin is an ideal organ to observe and analyze the impact of extrinsic and intrinsic drivers of aging. It is accessible not only to classical biochemical and immunohistochemical methods of analysis, but also, as it defines the outside of the body, to non‐ or minimally invasive methods of investigation. The recent years have brought an explosion of analytical capability in both classical and minimally invasive methods, which we will combine in this CD laboratory to analyze how the urban exposome and senescent cells affect skin metabolism, communication and quality control. We will use a multimodal approach, the combination of various pioneering analytical imaging techniques to investigate the initiation, promotion and chronic phases of cellular senescence in skin aging. Furthermore, we will also analyze and visualize the contribution of senescent cells to the deterioration of local microenvironments, which will promote a better understanding of the essential events in skin aging. Importantly, this visual and analytic approach allows investigating active substances for skincare that prevent or reverse deterioration of cellular metabolism and quality control.