Sources of indistinguishable single photons lie at the heart of many quantum computing protocols and other applications in quantum technologies. To date however, an efficient spectrally tuneable source for indistinguishable single photons that is integratable on a nanophotonic platform and works at room temperature remains elusive. This is a key bottleneck for quantum technologies. The here proposed applied research project “PhoQus2D” will address this and for the first time realize a tunable, waveguide‐chipintegrated room‐temperature indistinguishable single photon source. To this end, the recently discovered room‐temperature quantum emission colour centers in the two‐dimensional (2D) material hexagonal Boron nitride (hBN) will be utilized. "PhoQus2D" will integrate the quantum‐emitting 2D hBN for the first time within nanophotonic waveguide‐chips to allow efficient coupling of light. The realized single photon source will also be integrated with electrodes to realize tuneablity of the spectral quantum emission properties. To develop an intrinsically scalable technology, “PhoQus2D” will utilize scalable chemical vapour deposition (CVD), transfer and post‐processing of 2D hBN films. Key advantage of CVD 2D hBN films is their direct integrateability into planar device fabrication processes which are widely used in industrial opto‐electronic device fabrication. "PhoQus2D" will demonstrate the room‐temperature, waveguide‐chip‐integrated, tuneable single photon source at a technology readiness level (TRL) of 4. Thereby this exploratory project ("Sondierung") forms the ideal basis for further exploitation of the "PhoQus2D" technology via spin‐off foundation and/or collaborative work with industrial stakeholders in opto‐electronics. To achieve its challenging goals, “PhoQus2D” brings together a highly complementary and interdisciplinary project team at the Technische Universität Wien (TU WIEN): One the one hand, the TU WIEN's Atominstitut provides a proven background in solid‐state quantum emitters and their coupling to nanophotonic platforms. On the other hand, this is complemented by TU WIEN’s Institute of Materials Chemistry who has a proven trackrecord in scalable synthesis and integration of 2D materials incl. hBN. This combination of expertise in quantum technology and scalable materials fabrication is unique and ensures the realization and scalabilityof the ambitious and ground‐breaking work proposed in "PhoQus2D".