Gain of insights to the fundamental processes of the metabolism of bone, including cellular activities and interactions, the influences of mechanical and biochemical environment of bone, as well as diseases. Students will be introduced to mathematical modeling approaches, aiming at improvement of the understanding (and prediction) of bone remodeling. Furthermore, the students will be made aware of another important aspect, namely bone pain.

1. Bone cells and interactions among them. Bird view.
2. Diseases of bone homeostasis
3. Spatial regulation of bone remodeling
4. Role of OPG in regulating RANKL-induced migration
5. Calcium and phosphate homeostasis and bone
6. Unusual effects of PTH on bone. Can we explain it?
7. Control of bone by mechanical forces
8. Mechanosensitivity by bone cells
9. Mechanotransduction among bone cells
10. Two-threshold idea of mechanosensitivity and mechanotransduction
11. Potential interactions between mechanical and homeostatic signaling in bone
12. Regulation of bone mineralization
13. Regulation of osteoclast formation – role of positive and negative feedbacks
14. Regulation of bone mineralization
15. Bioenergetics of bone cells
16. Challenges in studying regulation of energy metabolism
17. Cancer metastasis to bone
18. Osteoclast activation during cancer metastasis to bone
19. Pain related to bone disorders – how can we study it?
20. Link between osteolysis and pain