166.655 Integrated biopharmaceutical production in pilot scale
This course is in all assigned curricula part of the STEOP.
This course is in at least 1 assigned curriculum part of the STEOP.

2014S, LU, 6.0h, 6.0EC, to be held in blocked form

Properties

  • Semester hours: 6.0
  • Credits: 6.0
  • Type: LU Laboratory Exercise

Aim of course

Introduction to the complexity of integrated and automated production and purification of recombinant proteins by microbial hosts in pilot scale

Subject of course

Red Biotechnology

1) Comprehension of the physiological basic principles of recombinant protein production: Expression of an intracellular therapeutic or diagnostic protein / enzyme in E. coli

2) Complete bacterial process from seed to bioreactor production, over product isolation to product purification in a 60 - 250 L scale.

- Get introduced in the single unit operations, respective to hardware, instrumentation and automation

- Understand der support function and their operations: media buffer preparation, CIP, SIP and clean utilities

- Understand closed integrated processing and open handling operations

3) Process Automation: transition conditions, conditions to start of a unit operation, recipes, and basic function, Process management system

 

Additional information

The participation to the introductional meeting is mandatory

Each group is about 2 weeks in the lab.

The execution of the exersize is scheduled for June.

Lecturers

  • Herwig, Christoph
  • Wechselberger, Patrick
  • Klein, Tobias

Institute

Examination modalities

Incoming test, Execution, report, final discussion

Course registration

Begin End Deregistration end
01.10.2013 09:00 14.02.2014 09:00 21.02.2014 09:00

Group Registration

GroupRegistration FromTo
Pilotproduktion 101.10.2013 09:0014.02.2014 09:00
Pilotproduktion 201.10.2013 09:0014.02.2014 09:00
Pilotproduktion 301.10.2013 09:0014.02.2014 09:00

Curricula

Study CodeObligationSemesterPrecon.Info
066 490 Technical Chemistry Mandatory elective

Literature

No lecture notes are available.

Miscellaneous

  • Attendance Required!

Language

German