After successful completion of the course, students are able to explain and demonstrate the network of a broad spectrum of sicientific disciplines in biochemistry and molecular biology including:
- the dynamic of the genome (replication, recombination, transcription),
- the transcription and its regulation; maturation of RNA;
- the biosynthesis, maturation, transport and degradation of proteins
- aspects of protein chemistry including structure-activity relationships and enzymology
- the transport of molecules into, in and out of the cell
- anabolic and catabolic reactions
- a summary on secondary metabolism and its regulation
Dynamic of the genome (replication, recombination, transcription), mechanisms and involved proteins; transcription and its regulation; maturation of RNA; Biosynthesis, maturation, transport and degradation of proteins (translation, glycosylation and other modifications; secretory pathway, proteosome); Protein chemistry, examples of structure-activity relationships (dehydrogenases, oxidases, coat proteins, receptors, immunoglobulins and immune response); enzymology (catalytic mechanisms, kinetics of multiple substrate reactions); transport of molecules into the cell; anabolic and catabolic reactions (carbohydrates, lipids, amino acids, nucleotides) and their regulation; Secondary metabolism and its regulation
The lecturers will provide references for individual chapters during the course; the power point presentations can be obtained from the internet
nucleic acids, DNA, RNA, gen regulation: Molekulare Genetik Verlag: Thieme, Stuttgart; Auflage: 10., kompl. überarb. A. (2015)
Proteins, Enzymes: Principles of Biochemistry; Voet D, Voet JG, Pratt CW; Wiley; and Introduction to Protein Structure, C. Branden and J. Tooze, Garland.
