After successful completion of the course, students are able to apply general spects of pharmacodynamics and pharmacokinetics; they adopt an overview for the development of small-molecule drugs from the preclinical phase via clinical phases to market introduction. Students are familiarized with essential mode of action for small-molecule drugs and were introduced to general structure-activity relationships for core drug classes.
basics of drug activity (enzyme-drug interaction, pharmacodynamics, receptor concept, bioisosterism) drug mechanisms (enzyme inhibition and stimulation) development and structure optimization of drugs (SAR, COMFA, etc.) pro-drug/bio-precursor concept pharmacokinetics (ADME - absorption, distrubution, mebatolism, excretion) safety, toxicity, placebo effect regulatory aspects & intellectual property protection major classes of pharma drugs and agrochemicals incl. their corresponding mode of action
Scientific approach employing hypothesis develoment and application within representative examples; reflecting particular problem situations emphasizing on mechanistic aspects.
Context based discussion of representative and novel examples derived from the lecture, in particular considering also the knowledge-based content of the lecture.
