After successful completion of the course, students are able to describe the synthesis of different natural products and to explain and compare the required synthetic strategies, key reactions, and methods.

Learning about the total synthesis of molecules, with a focus on stereoselective synthesis. Methods include: coupling methods; stereoselective aldol reactions; stereoselective allylations; macrocyclisations, metathesis reactions; Sharpless epoxidation; glycosylation reactions; solid phase peptide synthesis; selective disulfide bond formation; protein ligations. These methods will be illustrated with specific natural product examples: Everinomycin; Epothilon; Vancomycin; Insulin; HIV1 protease; poly-ubiquitinated alpha-globin; Hexoses; Zaragozic acid; Brevetoxin. Contemporary applications of protein synthesis in biology and medicine will be briefly discussed.

Dates:

- 23.03.2023 (PG)
- 30.03.2023 (PG)
- 20.04.2023 (PG)
- 04.05.2023 (AC)
- 11.05.2023 (AC)
- 25.05.2023 (backup)
- 01.06.2023 (HM)
- 15.06.2023 (HM)

Powerpoint presentations, selected scientific publications

Sharpless-epoxidation + Hexosen (PG)

Dihydroxylation + Zaragozic acid (PG)

Polyethers + Brevetoxin (PG)

Peptide synthesis, disulfide bond formation + insulin (AC)

Protein ligations + HIV1 protease, poly-ubiquitinated alpha-globin (AC)

Glycosylation + Everninomicin (HM)

Makrocyclisation, methathesis + Epothilon (HM)

Atropisomerism + Vancomycin (HM)

Oral examination