163.043 Organic Molecular Chemistry
This course is in all assigned curricula part of the STEOP.
This course is in at least 1 assigned curriculum part of the STEOP.

2022W, VO, 3.0h, 4.5EC


  • Semester hours: 3.0
  • Credits: 4.5
  • Type: VO Lecture
  • Format: Online

Learning outcomes

After successful completion of the course, students are able to carry out a retrosynthonal disconnection of a molecule of medium complexity and write down a reasonable forward synthesis considering knowledge from Organic Chemistry courses. They know the basics of stereochemistry and stereoselective synthesis, and the application of molecular orbital theory to describe organic chemical reactions.

Subject of course

Module 1: Strategies in Synthesis Planning: Principals of retrosynthesis, strategies for the design of monofunctional aliphatic and cycloaliphatic structures as well as aromatic substitution pattern; concepts for the synthesis of di- and polyfunctional products in dependence from the distance of the functional groups; umpolung of reactivity; latent functionalities. Strategies for building up heterocyclic ring systems. General concepts for the synthesis of more complex organic structures.  Protecting groups chemistry (Prerequisites for protecting groups; concept of orthogonal protecting groups; Introduction, cleavage and selectivity of protecting groups for importantfunctional groups like alcohols, diols, amines, carbonyl groups, and carboxylic acids).

Module 2: Foundations of stereochemistry and stereoselective syntheses:  Structure, stereoisomerism, symmetry, configuration, properties of stereoisomers, chiro-optical properties, separation of stereoisomers, heterotope ligands and planar structures, stereochemistry of alkenes, conformation of acyclic molecules, configuration and conformation of cyclic molecules, chirality of molecules without chiral centres. Asymmetric synthesis: chiral auxilaries; chiral reagents; several types of reactions; non-linear effects; Zimmermann-Traxler-model; double stereodifferentiation.

Module 3: Molecular orbitals and organic chemical reactions: Molecular orbital theory and its implications for the structure and reactivity (incl. kinetics) of organic molecules.

Teaching methods

Module 1: Retrosynthesis is demonstrated on board by M. Schnürch with constant questions to the students.

Module 2: Advanced stereochemistry and concepts of asymmetric synthesis will be described and discussed.

Module 3: The implications and applications of molecular orbital theory will be described in a simplified non-mathematical form and discussed with the students by means of and supported by several examples.

Mode of examination


Additional information

1. Block-VO Schröder (module 2)

2. Block-VO Mikula (module 3)

3. Block-VO Schnürch (module 1)



Course dates

Thu09:00 - 11:0017.11.2022 - 26.01.2023Seminarraum Lehar 03 Vorlesung
Fri11:00 - 13:0016.12.2022Seminarraum Lehar 03 Vorlesung
Wed10:00 - 12:0011.01.2023Seminarraum Lehar 02 Vorlesung
Fri11:00 - 13:0013.01.2023Seminarraum Lehar 03 Vorlesung
Mon09:00 - 11:0016.01.2023 - 23.01.2023Seminarraum Lehar 03 Vorlesung
Fri10:00 - 12:0027.01.2023Seminarraum Lehar 03 Ersatztermin für den 19.1.
Organic Molecular Chemistry - Single appointments
Thu17.11.202209:00 - 11:00Seminarraum Lehar 03 Vorlesung
Thu24.11.202209:00 - 11:00Seminarraum Lehar 03 Vorlesung
Thu01.12.202209:00 - 11:00Seminarraum Lehar 03 Vorlesung
Thu08.12.202209:00 - 11:00Seminarraum Lehar 03 Vorlesung
Thu15.12.202209:00 - 11:00Seminarraum Lehar 03 Vorlesung
Fri16.12.202211:00 - 13:00Seminarraum Lehar 03 Vorlesung
Wed11.01.202310:00 - 12:00Seminarraum Lehar 02 Vorlesung
Thu12.01.202309:00 - 11:00Seminarraum Lehar 03 Vorlesung
Fri13.01.202311:00 - 13:00Seminarraum Lehar 03 Vorlesung
Mon16.01.202309:00 - 11:00Seminarraum Lehar 03 Vorlesung
Thu19.01.202309:00 - 11:00Seminarraum Lehar 03 Vorlesung
Mon23.01.202309:00 - 11:00Seminarraum Lehar 03 Vorlesung
Thu26.01.202309:00 - 11:00Seminarraum Lehar 03 Vorlesung
Fri27.01.202310:00 - 12:00Seminarraum Lehar 03 Ersatztermin für den 19.1.

Examination modalities

Written exam (120 min) on the content of all three parts of this course:

- Retrosynthesis: 2 question (2 x 20 points)

- Stereochemistry/Asymmetric synthesis: 4 questions (4 x 10 points)

- Molecular orbital theory: 2 questions (2 x 10 points)

A maximum of 100 points can be reached. Grades: S1 (89-100), U2 (76-88), B3 (63-75), G4 (50-62) and N5 (<50). In the case of N5 the exam needs to be repeated to complete this course.


DayTimeDateRoomMode of examinationApplication timeApplication modeExam
Fri14:00 - 16:0021.06.2024GM 2 Radinger Hörsaal - TCH written27.05.2024 00:01 - 17.06.2024 23:59TISSPrüfung 21.06.2024
Wed14:00 - 16:0014.08.2024GM 2 Radinger Hörsaal - TCH written22.07.2024 00:01 - 11.08.2024 23:59TISSPrüfung 14.08.2024

Course registration

Begin End Deregistration end
05.10.2022 11:00 30.11.2022 10:00 30.11.2022 01:00

Registration modalities

Eine Anmeldung ist wegen dem Abgleich mit der Hörsaalgröße und maximalen Belefung erforderlich


Study CodeObligationSemesterPrecon.Info
066 490 Technical Chemistry Mandatory elective
066 491 Technical Chemistry - Synthesis Mandatory


No lecture notes are available.

Previous knowledge

LVA der anorg. und organ. Chemie / Bachelor