163.043 Organic Molecular Chemistry
This course is in all assigned curricula part of the STEOP.
This course is in at least 1 assigned curriculum part of the STEOP.

2021W, VO, 3.0h, 4.5EC
TUWEL

Properties

  • Semester hours: 3.0
  • Credits: 4.5
  • Type: VO Lecture
  • Format: Distance Learning

Learning outcomes

After successful completion of the course, students are able to carry out a retrosynthonal disconnection of a molecule of medium complexity and write down a reasonable forward synthesis considering knowledge from Organic Chemistry courses. They know the basics of stereochemistry and stereoselective synthesis, and the application of molecular orbital theory to describe organic chemical reactions.

Subject of course

Module 1: Strategies in Synthesis Planning: Principals of retrosynthesis, strategies for the design of monofunctional aliphatic and cycloaliphatic structures as well as aromatic substitution pattern; concepts for the synthesis of di- and polyfunctional products in dependence from the distance of the functional groups; umpolung of reactivity; latent functionalities. Strategies for building up heterocyclic ring systems. General concepts for the synthesis of more complex organic structures.  Protecting groups chemistry (Prerequisites for protecting groups; concept of orthogonal protecting groups; Introduction, cleavage and selectivity of protecting groups for importantfunctional groups like alcohols, diols, amines, carbonyl groups, and carboxylic acids).

Module 2: Foundations of stereochemistry and stereoselective syntheses:  Structure, stereoisomerism, symmetry, configuration, properties of stereoisomers, chiro-optical properties, separation of stereoisomers, heterotope ligands and planar structures, stereochemistry of alkenes, conformation of acyclic molecules, configuration and conformation of cyclic molecules, chirality of molecules without chiral centres. Asymmetric synthesis: chiral auxilaries; chiral reagents; several types of reactions; non-linear effects; Zimmermann-Traxler-model; double stereodifferentiation.

Module 3: Molecular orbitals and organic chemical reactions: Molecular orbital theory and its implications for the structure and reactivity (incl. kinetics) of organic molecules.

Teaching methods

Module 1: Retrosynthesis is demonstrated on board by M. Schnürch with constant questions to the students.

Module 2: Advanced stereochemistry and concepts of asymmetric synthesis will be described and discussed.

Module 3: The implications and applications of molecular orbital theory will be described in a simplified non-mathematical form and discussed with the students by means of and supported by several examples.

Mode of examination

Written

Additional information

1. Block-VO Schröder (module 2)

2. Block-VO Schnürch (module 1)

3. Block-VO Mikula (module 3)

Lecturers

Institute

Course dates

DayTimeDateLocationDescription
Wed11:00 - 13:0017.11.2021 - 26.01.2022CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu11:00 - 13:0018.11.2021 - 27.01.2022CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Organic Molecular Chemistry - Single appointments
DayDateTimeLocationDescription
Wed17.11.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu18.11.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Wed24.11.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu25.11.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Wed01.12.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu02.12.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu09.12.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Wed15.12.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu16.12.202111:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Wed12.01.202211:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu13.01.202211:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Wed19.01.202211:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu20.01.202211:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Wed26.01.202211:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie
Thu27.01.202211:00 - 13:00CAD-Labor Saal 1 und 2 Vorlesung 163.043 Organische Molekularchemie

Examination modalities

Written exam (120 min) on the content of all three parts of this course:

- Retrosynthesis: 2 question (2 x 20 points)

- Stereochemistry/Asymmetric synthesis: 4 questions (4 x 10 points)

- Molecular orbital theory: 2 questions (2 x 10 points)

A maximum of 100 points can be reached. Grades: S1 (89-100), U2 (76-88), B3 (63-75), G4 (50-62) and N5 (<50). In the case of N5 the exam needs to be repeated to complete this course.

Exams

DayTimeDateRoomMode of examinationApplication timeApplication modeExam
Fri13:00 - 15:0017.12.2021GM 2 Radinger Hörsaal - TCH written26.11.2021 00:01 - 13.12.2021 23:59TISSPrüfung 17.12.2021

Course registration

Begin End Deregistration end
06.10.2021 11:00 10.11.2021 10:00 17.11.2021 01:00

Registration modalities

Eine Anmeldung ist wegen dem Abgleich mit der Hörsaalgröße und maximalen Belefung erforderlich

Curricula

Literature

No lecture notes are available.

Previous knowledge

LVA der anorg. und organ. Chemie / Bachelor

Language

German