After successful completion of the course, students are able to understand basic biochemical, biological and medical processes in which inorganic compounds, especially coordination bonds of transition metals play an essential role.
Biological meaning (of inorganic) of elements of the periodic table. Chemical, physical and thermodynamic relations: Speciation and their meaning (for example: H+, Zn2+, Fe2/3+), availability of the elements under anaerobic and aerobes conditions. Meaning of Lewis and Broensted acid and bases concepts in hydrophobic and hydrophilic environments: Complex formation and protonation-diprotonation reactions. Kinetic effects. Fe-integration, storage and transprot. Redox reactions: Redox active species, oxygen activation. The indivitual role elements: Alkali, alkaline earth metals, zinc, active centres in metal proteins: (Fe, Mn, Cu, Ni, CO, Mo, V, etc.) Bio-mineralization: biological crystallization and morphology. Medical aspects: Tracer items, cis platinum, Desferrioxamin. Hypotheses for the origin of the life (clay minerals, Fe-sulphides, cu hypothesis, etc.)
